TABLE 2.
KSHV virion proteins identified by mass spectrometry
| Category and gene | Protein | Size (amino acids:) | Homolog in:
|
Function | ||
|---|---|---|---|---|---|---|
| HSV-1 | HCMV | EBV | ||||
| Capsid proteins | ||||||
| ORF17.5 | VP17.5 | 282 | UL26.5 | UL80 | BVRF2 | SCAF |
| ORF25 | VP25 | 1,376 | UL19 | UL86 | BCLF1 | MCP |
| ORF26 | VP26 | 305 | UL18 | UL85 | BDLF1 | TRI-2 |
| ORF62 | VP62 | 331 | UL38 | UL46 | BORF1 | TRI-1 |
| ORF65 | VP65 | 170 | UL35 | UL48/49 | BFRF3 | SCIP |
| Envelope proteins | ||||||
| ORF8 | gB | 845 | UL27 | UL55 | BALF4 | gB |
| K8.1 | gp35/37 | 228 | Glycoprotein | |||
| ORF22 | gH | 730 | UL22 | UL75 | BXLF2 | gH |
| ORF28 | 102 | BDLF3 | Homologous to EBV gp150 | |||
| ORF39 | gM | 399 | UL10 | UL100 | BBRF3 | gM |
| ORF47 | gL | 167 | UL1 | UL115 | BKRF2 | gL |
| ORF53 | gN | 110 | UL49.5 | UL73 | BLRF1 | gN |
| ORF68 | 545 | UL32 | UL52 | BFLF1 | Glycoprotein | |
| Tegument proteins | ||||||
| ORF21 | VP21 | 580 | UL23 | BXLR1 | TK | |
| ORF33 | VP33 | 334 | UL16 | UL94 | BGLF2 | |
| ORF45 | VP45 | 407 | BKRF4 | IRF-7 binding protein | ||
| ORF63 | VP63 | 927 | BOLF1 | Tegument protein | ||
| ORF64 | VP64 | 2,635 | UL36 | UL48 | BPLF1 | Tegument protein |
| ORF75 | VP75 | 1,296 | BNRF1 | Tegument protein | ||
| Other (uncategorized) | ||||||
| ORF6 | VP6 | 1,133 | UL29 | UL57 | BALF2 | Single-stranded DNA binding protein |
| ORF7 | VP7 | 695 | UL28 | UL56 | BALF3 | Transport protein |
| ORF11 | VP11 | 407 | Raji LF2 | Homologous to EBV LF2 | ||
| ORF27 | VP27 | 290 | BDLF2 | |||
| ORF52 | VP52 | 131 | BLRF2 | |||