Table 1.
Previous reports of patients with acute basophilic leukemia or acute myeloid leukemia with basophilic differentiation transformed from myelodysplastic syndrome. M, male; F, female; RA, refractory anemia; RAEB, refractory anemia with excess blasts; RCMD, refractory cytopenia with multilineage dysplasia; ND, not described; IP, interstitial pneumonia.
| Case | Age/sex | Diagnosis | Interval from diagnosis to transformation | Karyotype at transformation | Outcome | prognosis from transformation | Reference |
|---|---|---|---|---|---|---|---|
| 1 | 52/F | RAEB | 2 months | Complex karyotype including -7 | Death of disease | 6 months | Shirakawa et al., 1992 |
| 2 | 52/F | RA | 2 years | del(5)(q31q35) | Death due to IP | 2 months | Yamagata et al., 1995 |
| 3 | 84/F | ND | 2 months | Complex karyotype including -7 | ND | ND | Wells et al., 2014 |
| 4 | 64/M | RCMD | 2 months | Complex karyotype including -7 | ND | ND | Bahmanyar and Chang, 2016 |
| 5 | 81/M | RAEB-1 | 3 months | -7, add(1)(q21) | Death of bronchopneumonia | 6 months | This case |