. Author manuscript; available in PMC: 2017 Apr 10.

Published in final edited form as: Nat Rev Dis Primers. 2016 May 19;2:16033. doi: 10.1038/nrdp.2016.33

Table 2.

Assessment of quality of life in PHPT

Study	Quality of life and neurocognition	Psychological symptoms
*Prospective study*
Walker et al.¹⁶³	Worse scores for immediate and delayed recall of contextually related material (Wechsler Memory Scale Logical Memory Test) in patients with PHPT compared with controls, both of which improved 6 months after parathyroidectomy; non-verbal abstraction (Booklet Category Test) was worse compared with controls and improved after parathyroidectomy	More symptoms of depression (Beck Depression Index), and state and trait anxiety (State-Trait Anxiety Inventory) in patients with PHPT compared with controls; significant improvements in depression and trait anxiety 6 months after parathyroidectomy
*Randomized controlled trials*
Rao et al.¹²⁹	Modest but significant improvements in social functioning and emotional role functioning in individuals 1 year after parathyroidectomy compared with medical management (SF-36)	Modest but significant improvements in anxiety and phobia in individuals 1 year after parathyroidectomy compared with medical management (SCL-90-R)
Ambrogini et al.¹³⁰	Modest but significant beneficial effects on bodily pain, general health perception, vitality and mental health in individuals 1 year after parathyroidectomy compared with medical management (SF-36)	No between-group differences 1 year after parathyroidectomy (SCL-90-R)
Bollerslev et al.¹³¹	Modest but significant improvements in mental health and the mental component summary scores 1 year, but not two years, after parathyroidectomy compared with medical management (SF-36)	No between-group differences (Comprehensive Psychopathological Rating Scale)

PHPT, primary hyperparathyroidism; SCL-90-R, Symptom Checklist-90-Revised scale; SF-36, 36-Item Short-Form Health Survey.