Table 4.
Effect of copy number in genes and intergenic regions on body mass index and waist circumference.
| Factor | Type | β (95% CI)a | p | |
|---|---|---|---|---|
| Gene | ||||
| LEPR (intron 2) | BMI | Gain | −0.26 (−1.51; 0.98) | 0.677 |
| WC | −1.37 (−4.64; 1.91) | 0.413 | ||
| LEPR (intron 3) | BMI | Gain | −0.50 (−1.01; 0.02) | 0.057 |
| WC | −1.85 (−3.21; −0.49) | 0.008 | ||
| NEGR1 | BMI | Gain | −0.64 (−1.10; −0.19) | 0.006 |
| WC | −2.03 (−3.24; −0.83) | 0.001 | ||
| ARHGEF4 | BMI | Gain | 0.63 (0.11; 1.15) | 0.017 |
| WC | 1.45 (0.09; 2.81) | 0.037 | ||
| CPCXR1 | BMI | Gain | 0.66 (0.21; 1.11) | 0.004 |
| WC | 2.10 (0.89; 3.30) | 0.001 | ||
| INS | BMI | Loss | 0.77 (0.30; 1.25) | 0.002 |
| WC | 2.20 (0.94; 3.45) | 0.001 | ||
|
| ||||
| Intergenic regions | ||||
| 1p36.33b | BMI | Gain | 0.06 (−0.46; 0.57) | 0.829 |
| WC | −0.13 (−1.47; 1.21) | 0.852 | ||
| 12q15c | BMI | Gain | 0.88 (0.36; 1.41) | 0.001 |
| WC | 2.04 (0.65; 3.43) | 0.004 | ||
| 15q21.1a | BMI | Gain | 0.67 (0.20; 1.14) | 0.005 |
| WC | 1.98 (0.75; 3.21) | 0.002 | ||
| 22q11.21d | BMI | Gain | 1.09 (0.59; 1.59) | <0.0001 |
| WC | 2.61 (1.29; 3.92) | <0.0001 | ||
aLinear regression models adjusted for age, gender, and family history of obesity. Children with 2 copies were chosen as the reference group. BMI: body mass index; WC: waist circumference.