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. 2017 Mar 24;2017:5053035. doi: 10.1155/2017/5053035

Figure 7.

Figure 7

OTX008 suppresses retinal neovascularization (RNV) and attenuates retinal hypoxia. (a) RA group. (b) OIR-OTX008 group. (c) OIR group. (d) OIR-PBS group. At P17, whole-mount retinas were stained by isolectin B4 (red) and Hypoxyprobe (green). White arrows indicate neovascular tufts. Black arrows show hypoxic zones. Irregular loops depict VO areas. Magnification 40x, scale bar = 500 μm. (e–g) Quantification of RNV, vaso-obliteration (VO), and hypoxic zones. RNV, VO, and hypoxia zones were decreased from the OIR-OTX008 group compared to the OIR group and to the OIR-PBS group. RA versus OIR, t = 11.46, t = 14.56, t = 11.94, ∗∗∗P < 0.001; OIR-OTX008 versus OIR, t = 5.459, t = 5.807, t = 5.686, ∗∗∗P < 0.001, OIR-OTX008 group versus OIR-PBS group, t = 5.170, t = 5.886, t = 4.639, ∗∗∗P < 0.001; data were presented as the mean ± SD, n = 10 per group.