FIG. 1.

Degrees of insulitis and inflammatory cell compositions in nonvirally infected NOD, NOD IL-4^−/−, and NOD IFN-γ^−/− mice. The insulitic infiltrate of 12-week-old NOD IFN-γ^−/− females was quantitatively and qualitatively equivalent to those of NOD and NOD IL-4^−/− mice at 8 weeks of age. At 8 (A) and 12 (B) weeks of age, two pools of dispersed islet cells (generated from three mice each) were prepared from NOD (black bars), NOD IL-4^−/− (gray bars), and NOD IFN-γ^−/− (white bars) females. Data in the left panels represent the mean proportions ± standard deviations of CD45-expressing leukocytes within the two islet cell pools prepared from each type of donor. The right panels depict the mean proportions ± standard deviations of CD4 T cells, CD8 T cells, B cells, and macrophages/DC among the CD45-positive leukocytes within the two islet cell pools of each donor type.