FIG. 2.

Effect of a CVB4 challenge on development of diabetes in NOD mice. A challenge of NOD mice with the CVB4 Edwards strain differentially accelerates or inhibits the onset of diabetes in NOD mice. As observed previously (22), a challenge of female NOD mice at 8 weeks of age can either induce a rapid onset of overt diabetes (i.e., within 2 weeks) or impart long-term protection. Kaplan-Meier life-table analysis was utilized to compare the rates of diabetes for saline-treated and CVB4-challenged animals. P = 0.01 for the onset of diabetes within 2 weeks of viral challenge.