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. 2005 Jan;79(2):1045–1052. doi: 10.1128/JVI.79.2.1045-1052.2005

FIG. 3.

FIG. 3.

Effect of CVB4 challenge on development of diabetes in cytokine-disrupted NOD mice. (A) Compared to saline-treated controls, there was a trend towards disease protection in NOD IL-4−/− females challenged with CVB4 at 8 weeks of age. Kaplan-Meier life-table analysis was utilized to compare the rates of diabetes for saline-treated and CVB4-infected animals. P = 0.06 for the difference in the rates of diabetes development throughout the study. (B) Acceleration of type 1 diabetes relative to saline-treated controls was not observed for NOD IFN-γ−/− mice challenged with CVB4 at 8 weeks of age. Kaplan-Meier life-table analysis was utilized to compare the rates of diabetes for saline-treated and CVB4-challenged animals. P = 0.01 for the difference in the rates of diabetes development throughout the study.