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Representative images from pancreases of NOD and cytokine-disrupted NOD mice 7 days after CVB4 infection. Animals (n = 3/strain) were 10 to 11 weeks old at the time of CVB4 infection. The slides were processed by routine methods and stained with hematoxylin and eosin. Intensive acinar infiltration and destruction were present in NOD (A), NOD IL-4−/− (B), and NOD IFN-γ−/− (C) mice. The images are representatives from a single animal of each strain. Magnification, ×20.
