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Arrangements of proteins in replicase polyprotein in HKU1 compared with those in HCoV-OC43, BCoV, and MHV. Alignment of the AC domains of HCoV-OC43, BCoV, and MHV and the AC domains and ATR (underlined) of CoV-HKU1 in the two patients was generated with ClustalX 1.83. AC domain, acidic domain. GenBank accession numbers are as follows: MHV, NC_001846; BCoV, NC_003045; HCoV-OC43, AY585229.
