Table 3.
Univariate and multivariate predictors of successful liberation from prolonged mechanical ventilation
| Variables | Binary logistic regression analysis | |||
|---|---|---|---|---|
| Univariate | Multivariate | |||
| OR (95%CI) | p value | AOR (95%CI) | p value | |
| Age (years) | ||||
| < 40 | 1.57 (0.49 - 5.618) | 0.540 | ||
| 40 - 70 | 0.50 (0.14 - 1.77) | 0.360 | ||
| Sex | ||||
| Male (versus female) | 0.51 (0.13 - 1.97) | 0.517 | ||
| Co-morbidities | ||||
| Diabetes mellitus | 0.54 (0.14 - 1.95) | 0.497 | ||
| Chronic obstructive pulmonary disease | 3.44 (0.16 - 70.90) | 0.540 | ||
| Cardiomyopathy | 1.35 (0.12 - 14.20) | 1.000 | ||
| Chronic kidney disease | 0.17 (0.02 - 1.07) | 0.060 | ||
| Medical illness | 0.30 (0.03 - 2.76) | 0.410 | ||
| SOFA (at admission) | -0.07 | 0.450 | ||
| APACHE II (at admission) | 0.03 | 0.640 | ||
| Reason for initiation of MV | ||||
| Low Glasgow Coma Scale score | 0.77 (0.23 - 2.62) | 0.760 | ||
| Pneumonia | 0.80 (0.23 - 2.71) | 0.760 | ||
| Aspiration | 0.35 (0.09 - 1.27) | 0.170 | ||
| Sepsis | 1.04 (0.28 - 3.80) | 1.000 | ||
| ARDS | 1.44 (0.32 - 6.30) | 0.730 | ||
| Mild | 1.35 (0.12 - 14.20) | 1.000 | ||
| Moderate | 3.44 (0.16 - 70.98) | 0.540 | ||
| Severe | 0.62 (0.09 - 4.21) | 0.630 | ||
| Clinical course during ICU stay | ||||
| PEEP (Maximum) | 0.12 | 0.460 | ||
| Duration of vasopressor support (days) | 0.12 | 0.004 | 0.11 | 0.042 |
| Duration of MV (days) | 0.01 | 0.380 | ||
| Acute kidney injury | 0.23 (0.02 - 2.05) | 0.240 | ||
| Need for hemodialysis | 0.06 (0.01 - 0.33) | 0.0004 | 0.67 (0.07 - 0.92) | 0.018 |
| Use of sedative drugs | 0.41 (0.01 - 9.27) | 1.000 | ||
| Presence of delirium | 1.33 (0.38 - 4.57) | 0.750 | ||
| Neuromuscular blockade | 0.61 (0.18 - 2.08) | 0.530 | ||
OR - odds ratio; 95%CI - 95% confidence interval; AOR - adjusted odds ratio; SOFA - Sequential Organ Dysfunction Assessment; APACHE II - Acute Physiology and Chronic Health Evaluation II; MV - mechanical ventilation; ARDS - acute respiratory distress syndrome; ICU - intensive care unit; PEEP - positive end-expiratory pressure. Outcome (success or failure): for categorical variables, odds ratio (95% confidence interval) [p value], for continuous variables. Beta coefficient [p value]. Factors with a p value < 0.05 in the univariate analysis were included in the multivariate analysis. Statistical significance was indicated when p value < 0.05.