Table 6.

miRNA levels in plasma and plasma-derived exosomes.

Diagnosis	Pre/Post	miR-lOb		miR-21		miR-30c		miR-106b		miR-20a		miR-181a
Diagnosis	Pre/Post	P	Exo	P	Exo	P	Exo	P	Exo	P	Exo	P	Exo
Normal (N = 6)	Pre	0.92 ± 0.21	1.13 ± 0.25	1.08 ± 0.23	1.04 ± 0.18	0.85 ± 0.23	0.74 ± 0.03	0.73 ± 0.19	1.09 ±0.24	1.25 ± 0.30	1.01 ± 0.15	1.00 ± 0.07	0.90 ± 0.12
CP (N = 11)	Pre	0.76 ±0.14	1.04 ± 0.10	1.01 ± 0.11	0.94 ±0.16	0.83 ± 0.18	0.74 ±0.11	1.20 ± 0.21	0.93 ±0.17	1.63 ± 0.29	0.95 ±0.12	0.80 ± 0.18	1.49 ± 0.27
	Post	0.66 ± 0.08	0.95 ± 0.10	1.20 ± 0.21	0.88 ± 0.12	0.72 ± 0.17	0.78 ± 0.13	0.89 ± 0.11	0.81 ±0.12	1.93 ± 0.31	0.72 ±0.15	0.75 ± 0.18	1.65 ± 0.29
PDAC (N = 29)	Pre	12.11 ± 1.38^**	34.76 + 6.24^**^†	5.34 ± 0.66^**	7.93 ± 1.52^**	9.77 ± 1.48^**	31.71 + 7.04^**^†	5.21 ± 0.62^**	4.03 ± 0.74^*	6.00 ± 0.55^**	2.59 + 0.18^**^†	3.06 ± 0.34^*	8.45 + 0.88^*1
	Post	1.87 ±0.19^##	3.37 ± 0.47^†^##	2.12 ± 0.33^##	1.61 ± 0.15^##	2.12 ± 0.27^**	2.60 ± 0.31^##	1.56 ± 0.21^##	1.28 ±0.09^##	2.00 ± 0.21^##	1.28 ± 0.10^†^##	2.65 ± 0.32	5.65 ± 0.60^†^#⁺

Diagnosis	Pre/Post	miR-483		miR-let7a		miR-122
Diagnosis	Pre/Post	P	Exo	P	Exo	P	Exo
Normal (N = 6)	Pre	1.27 ± 0.14	1.21 ± 0.15	1.01 ± 0.04	0.97 ± 0.06	1.08 ± 0.19	1.00 ± 0.08
CP (N = 11)	Pre	1.33 ± 0.20	1.40 ± 0.43	1.66 ± 0.25	1.60 ± 0.26	1.21 ± 0.25	1.47 ± 0.34
	Post	1.45 ± 0.25	1.25 ± 0.26	1.46 ± 0.15	1.60 ± 0.18^†	1.51 ± 0.38	1.21 ± 0.11
PDAC (N = 29)	Pre	2.23 ± 0.32	1.77 ± 0.31	0.56 ± 0.04^**	0.40 ± 0.03^**^†	0.52 ± 0.04^**	0.39 ± 0.04^**^†
	Post	2.07 ± 0.23	2.27 ± 0.34	1.48 ± 0.09^##	1.70 ± 0.12^##	3.93 ± 0.57^**	1.77 ± 0.10^†^##⁺

Data are based on assays using plasma (P) or exosomes (Exo) from 6 normal controls, 11 chronic pancreatitis (CP) patients, and 29 patients with pancreatic ductal adenocarcinoma (PDAC). Data were analyzed by ANOVA followed by Bonferroni adjustment.

p < 0.01, and

^**

p < 0.001 by comparison with corresponding values in normal or CP plasma or exosomes;

^†

p < 0.02 by comparison with corresponding values in plasma;

p < 0.05 and

^##

p < 0.01 by comparison with corresponding pre-resection values;

⁺

p < 0.01 and by comparison with corresponding values in normal controls.