Skip to main content
. 2016 Feb 19;41(2):134–143. doi: 10.1016/j.jgr.2016.02.003

Fig. 3.

Fig. 3

Effects of Korean Red Ginseng extract (RGE) on the mitogen-activated protein kinase (MAPK) and nuclear factor kappa B (NF-κB) signaling pathway in 1-fluoro-2,4-dinitrobenzene (DNFB)-induced skin lesions. Protein was isolated from normal or DNFB-induced dermatitis dorsal skin. (A) Phosphorylation levels of extracellular signal-regulated kinase (ERK), c-jun N-terminal kinase (JNK), and p38 was assayed by a Western blot analysis. (B) Relative levels of p-ERK, p-JNK, and p-p38 were calculated using an image analyzer. Values represent the mean ± standard deviation (SD) of independent experiments. (C) The degradation of IκBα and the translocation of NF-κB were assayed by a Western blot analysis. (D) The relative levels of IκBα and NF-κB were calculated using an image analyzer. Values represent the mean ± SD of independent experiments. *p < 0.05 versus blank and **p < 0.05 versus DNFB alone. Blank, DNFB-untreated normal mice; DNFB, DNFB-treated atopic dermatitis (AD) mice; RGE, DNFB-treated AD mice administered RGE after 4 wk of DNFB treatment; Pre-RGE, DNFB-treated AD mice administered RGE after the first DNFB treatment.