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. Author manuscript; available in PMC: 2017 Apr 10.
Published in final edited form as: JAMA. 2016 Oct 4;316(13):1383–1391. doi: 10.1001/jama.2016.14568

Figure 1. Odds ratio of coronary artery disease and type 2 diabetes associated with LDL-lowering genetic variants in or near investigated genes.

Figure 1

Coronary artery disease data were from 60,801 coronary artery disease cases and 123,504 controls from the CARDIoGRAMplusC4D Consortium.19 Type 2 diabetes data were from 50,775 cases of type 2 diabetes and 270,269 controls from EPIC-InterAct,13 UK Biobank14 and DIAGRAM.15 In addition to EPIC-InterAct,13 UK Biobank14 and DIAGRAM.15, type 2 diabetes association analyses of rs12916 at HMGCR included eleven studies (4,496 cases and 50,677 controls) previously reported by Swerdlow and colleagues.5 Therefore the sample size of HMGCR genetic variants association with type 2 diabetes was of up to 55,271 cases of type 2 diabetes and 320,946 controls. All results are scaled to represent the odds ratio per 1 mmol/L genetically-predicted reduction in LDL cholesterol. Abbreviations: SNP, single nucleotide polymorphism; OR, odds ratio; CAD, coronary artery disease; T2D, type 2 diabetes; LDL, low-density lipoprotein cholesterol.