Figure 1. Mitophagy induction upon oxidative and mitochondrial stress.

Transgenic nematodes expressing mtRosella in body wall muscle cells, were exposed to paraquat or CCCP. Mitophagy induction is signified by the reduction of the ratio between pH-sensitive GFP to pH-insensitive DsRed (n = 100; ***P < 0.001; one-way ANOVA). Arrowheads point out intestinal autofluorescence. Size bars denote 20 μm. Images were acquired using a 10x objective lens. Error bars denote SEM values.