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. 2015 Mar 26;5:9499. doi: 10.1038/srep09499

Figure 4. The TLR4 antagonist TAK-242 does not modify morphine-induced inhibition of murine upper GI transit in vivo.

Figure 4

Mice were injected i.p. with vehicle (VEH) or the TLR4 antagonist TAK-242 (4 mg/kg), and 30 min later saline or morphine (3 mg/kg) was injected s.c. Twenty min after injection of morphine, 5% Evans blue was gavaged. Upper GI transit is expressed as percentage of the distance travelled by the Evans blue bolus relative to the total length of the small intestine, measured 30 min after Evans blue administration. The values are means + SEM; n = 8–9. Main factor effect without interactions: ap < 0.001, morphine versus no morphine.