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. 2015 Apr 30;5:9658. doi: 10.1038/srep09658

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(A) Haplotypes shared among different continental groups. African populations are more likely to harbor haplotype CAGAGAC, while in non-African populations, haplotype CGGAGAC is much more pervasive, especially in East Asians in whom the haplotype frequency is nearly fixed. (B) Graphical depictions of SLC30A9 haplotypes constructed from 7 14nSNPs with haplotype frequencies derived from the 1000 Genomes Project. Hap1 (CAGAGAC) is the same as the haplotype in a chimpanzee (Chimp) and a Neanderthal (Nean). Hap2 (CGGAGAC) is different from Hap1 at rs1047626 of which the derived allele can alter an amino acid change from methionine acid to valine (M50V). (C) Predicted membrane topology of human SLC30A9 generated using HMMTOP and visualized with TeXtopo. Location of rs1047626 carried by the possible selected haplotype is indicated.