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. 2015 Apr 30;5:9802. doi: 10.1038/srep09802

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(A) p53-/- HCT116 cells lack p53 and have decreased p21 levels. Total lysates were separated by SDS-PAGE and blotted with the indicated antibodies. Gels were run under the same experimental conditions and blots were cropped for final display. (B) SMIFH2’s effects on the cytoskeleton are linked to p53 levels. p53-/- HCT116 cells were treated and stained in parallel with those displayed in Figure 2A. Scale bar, 10 µm.