Table 2. Ingenuity Pathway Analysis on early p53 response genes identified by Allen et al., 201474.
| Categories | Diseases or Functions Annotation | p-Value | Molecules | # Molecules |
|---|---|---|---|---|
| Cellular Movement | cell movement | 9,41E-07 | ACKR2,ACTA2,ALOX5,APAF1,BAX,BTG2,CD82,CDKN1A,COL17A1,COL4A1,DDB2,DGKA,DOCK8,DRAM1,EBI3,EFNB1,FAS,FBXW7,GDF15,GPR56,ICAM1,INPP5D,ITGA3,ITGA9,KCNN4,KDM4B,LAMA3,LRP1,mir-34,NTF3,NTRK2,PML,PRDM1,PRKX,PTP4A1,PTPRU,RHOD,SDC1,SERPINB5,TP53INP1,TRAF4,UNC5B,VCAN | 43 |
| Cellular Movement | migration of cells | 6,16E-06 | ACKR2,ACTA2,ALOX5,APAF1,BAX,BTG2,CD82,CDKN1A,COL17A1,COL4A1,DOCK8,EBI3,EFNB1,FAS,FBXW7,GPR56,ICAM1,INPP5D,ITGA3,ITGA9,KDM4B,LAMA3,LRP1,mir-34,NTF3,NTRK2,PML,PRDM1,PRKX,PTP4A1,PTPRU,RHOD,SDC1,SERPINB5,TP53INP1,TRAF4,UNC5B,VCAN | 38 |
| Cellular Movement | invasion of breast cancer cell lines | 1,83E-04 | CD82,CDKN1A,DDB2,DGKA,FAS,ITGA3,LRP1,mir-34,SERPINB5 | 9 |
| Cell-mediated Immune Response, Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking | T cell migration | 2,51E-04 | ACKR2,ALOX5,COL4A1,DOCK8,FAS,ICAM1,INPP5D,ITGA3,ITGA9 | 9 |
| Cellular Movement | invasion of tumor cell lines | 3,29E-04 | ACTA2,CD82,CDKN1A,DDB2,DGKA,DRAM1,FAS,GDF15,ITGA3,KDM4B,LRP1,mir-34,RHOD,SERPINB5,UNC5B,VCAN | 16 |
| Cellular Movement | invasion of cells | 3,47E-04 | ACTA2,CD82,CDKN1A,DDB2,DGKA,DRAM1,FAS,GDF15,ITGA3,KDM4B,LRP1,mir-34,NTRK2,RHOD,SDC1,SERPINB5,UNC5B,VCAN | 18 |
| Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking | Lymphocyte migration | 6,50E-04 | ACKR2,ALOX5,COL4A1,DOCK8,EFNB1,FAS,ICAM1,INPP5D,ITGA3,ITGA9 | 10 |
| Cellular Movement | cell movement of tumor cell lines | 7,44E-04 | ACTA2,CD82,CDKN1A,DDB2,DRAM1,EBI3,EFNB1,GDF15,KCNN4,KDM4B,LAMA3,LRP1,mir-34,NTF3,PTPRU,SDC1,SERPINB5,TP53INP1,TRAF4 | 19 |
| Cell-mediated Immune Response, Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking | cell movement of T lymphocytes | 2,53E-03 | ACKR2,COL4A1,DOCK8,FAS,ICAM1,INPP5D,ITGA3 | 7 |
| Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking | cell movement of mononuclear leukocytes | 2,82E-03 | ACKR2,ALOX5,COL4A1,DOCK8,EFNB1,FAS,ICAM1,INPP5D,ITGA3,ITGA9,UNC5B | 11 |
| Cellular Movement, Nervous System Development and Function | migration of neurons | 2,95E-03 | APAF1,BAX,COL4A1,EFNB1,GPR56,ITGA3,NTRK2 | 7 |
| Cellular Movement, Renal and Urological System Development and Function | migration of kidney cell lines | 3,90E-03 | EFNB1,ICAM1,PRKX,PTP4A1 | 4 |
| Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response | migration of phagocytes | 4,99E-03 | COL4A1,DOCK8,FAS,ICAM1,INPP5D,LRP1,SDC1 | 7 |
| Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking | migration of peripheral blood lymphocytes | 6,34E-03 | EFNB1,ICAM1 | 2 |
| Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking | cell movement of leukocytes | 6,60E-03 | ACKR2,ALOX5,CDKN1A,COL4A1,DOCK8,EFNB1,FAS,ICAM1,INPP5D,ITGA3,ITGA9,LRP1,PRDM1,SDC1,UNC5B | 15 |
| Cellular Movement | migration of epithelial cells | 6,64E-03 | CD82,COL17A1,ICAM1,LAMA3 | 4 |
| Cellular Movement, Hematological System Development and Function | migration of hematopoietic progenitor cells | 6,94E-03 | DOCK8,ICAM1,ITGA3 | 3 |
| Cell-mediated Immune Response, Cellular Movement, Hematological System Development and Function, Hematopoiesis, Immune Cell Trafficking | migration of thymocytes | 7,27E-03 | DOCK8,ITGA3 | 2 |
| Cellular Movement | migration of tumor cell lines | 8,25E-03 | ACTA2,CD82,CDKN1A,EBI3,EFNB1,KDM4B,LAMA3,LRP1,mir-34,NTF3,PTPRU,SDC1,TP53INP1,TRAF4 | 14 |
| Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response | migration of bone marrow-derived macrophages | 8,26E-03 | LRP1,SDC1 | 2 |
| Cell-To-Cell Signaling and Interaction, Cell-mediated Immune Response, Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking, Tissue Development | adhesion of regulatory T lymphocytes | 8,66E-03 | ICAM1 | 1 |
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