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. 2015 May 22;5:10414. doi: 10.1038/srep10414

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Copyright © 2015, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Carboplatin-P4C6 induced apoptosis of SKOV-3 cells and caused cell arrest in the S phase. (A) Dose-response curves for P4C6, CPt (=carboplatin) and CPt-P4C6 against SKOV-3 cells after 24 h incubation, and (B) corresponding IC₅₀ for P4C6, CPt and CPt-P4C6. Flow cytometric analysis of SKOV-3 cells treated with (C) 5 μM P4C6, (D) 1 μM CPt, and (E) 1 μM CPt-P4C6 for 24 h followed by treatment with the reagents in the Dead Cell Apoptosis Kit. (F) Cell cycle analysis of SKOV-3 cells treated for 12 h with negative control (cell culture media), 5 μM P4C6, 1 μM CPt, and 1 μM CPt-P4C6. Statistical analysis was performed using a Student’s t-test. Values of *P < 0.05 and ***P < 0.005 were considered statistically significant.