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. 2017 Apr 10;12(4):e0175498. doi: 10.1371/journal.pone.0175498

Fig 5. Irisin promoted pancreatic β cell proliferation via the ERK and p38 MAPK signaling pathways.

Fig 5

INS-1 cells were pretreated with PBS (as a vehicle control), U0 (U0126, 10 μM for 30 min) or SB (SB203580, 10 μM for 30 min), and then, the cells were cultured and treated with irisin (100 ng/ml) or vehicle. (A) The protein levels of total ERK, p-ERK, total p38 and p-p38 were determined by Western blot analysis. (B) The data are expressed as OD values at 450 nm and are reported as the mean ± SD. * P<0.05 compared with the control. # P<0.05 compared with the irisin-treated group.