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. 2017 Apr 10;12(4):e0175498. doi: 10.1371/journal.pone.0175498

Fig 6. Irisin attenuated apoptosis and improved the insulin secretion induced by high glucose in INS-1 cells.

Fig 6

(A) INS-1 cells were pretreated with PBS (control) or high glucose (25 mmol/l) for 24 h and then incubated with or without 100 ng/ml irisin for another 24 h. Apoptosis of INS-1 cells was detected by annexin V-FITC/PI staining. (B) The insulin levels were detected from cell-free supernatant after incubation with glucose at 16.7 mmol/l for 1 h. The data are expressed as the mean ± SD. * P<0.05 compared with the control. # P<0.05 compared with the high-glucose group.