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. 2017 Mar 27;13(3):e1006687. doi: 10.1371/journal.pgen.1006687

Fig 3. Opposing β-catenin and Tbx1 conditional mutants have same effect on expression of pro-differentiation genes in the AHF.

Fig 3

(A) Comparison of global gene expression changes in the micro-dissected AHF of β-catenin GOF and Tbx1 LOF embryos at E9.5. Plotted are differentially expressed genes (p < 0.05 and FC > 1.5) in at least one of the two comparisons, Tbx1 LOF vs controls (x-axis) or β-catenin GOF vs controls (y-axis). (B) Comparison of global gene expression changes in the micro-dissected AHF from Tbx1 GOF and β-catenin LOF embryos at E9.5. Plotted are differentially expressed genes (p < 0.05 and FC > 1.5) in at least one of the two comparisons, Tbx1 GOF vs controls (x-axis) or β-catenin LOF vs controls (y-axis). Red dots denote cardiac differentiation genes. (C) qRT-PCR analysis of Tbx1 LOF versus β-catenin LOF (FC = Fold Change) of selected genes demonstrating the opposite gene expression changes in these mutant embryos.