Table 2. Results of gene-based analysis in discovery data and replication cohorts.
| Methods | CFS | ARIC | WHI | BioVU | HRS | Meta of replication cohorts a | |
|---|---|---|---|---|---|---|---|
| SBP | |||||||
| Rare variants | Burden | 2.14E-3 | 5.72 E-3 | 6.68E-1 | 3.44E-1 | 6.95E-2 | 1.71E-2 |
| SKAT | 7.02E-2 | 2.59E-3 | 6.71E-1 | 1.13E-1 | 1.19E-1 | 6.35E-3 | |
| SKAT-O | 4.03E-3 | 3.56E-3 | 8.14E-1 | 1.79E-1 | 1.15E-1 | 1.26E-2 | |
| DBP | |||||||
| Rare variants | Burden | 1.48E-2 | 3.28E-1 | 4.08E-1 | 9.44E-1 | 1.20E-1 | 3.98E-1 |
| SKAT | 4.94E-2 | 4.61E-1 | 7.58E-1 | 3.98E-2 | 3.01E-1 | 2.05E-1 | |
| SKAT-O | 2.58E-2 | 4.75E-1 | 5.71E-1 | 6.42E-2 | 2.41E-1 | 2.05E-1 | |
| PP | |||||||
| Rare variants | Burden | 8.13E-2 | 1.40E-3 | 2.31E-1 | 2.52E-1 | 1.44E-1 | 3.77E-3 |
| SKAT | 1.27E-1 | 2.73E-4 | 5.11E-1 | 4.23E-1 | 1.27E-1 | 2.66E-3 | |
| SKAT-O | 1.28E-1 | 3.92E-4 | 3.45E-1 | 3.80E-1 | 1.23E-1 | 2.34E-3 | |
| BMI | |||||||
| Rare variants | Burden | 4.24E-3 | 4.35E-1 | N/A | 6.40E-1 | 7.26E-1 | 7.84E-1 |
| SKAT | 4.28E-4 | 6.50E-1 | N/A | 7.80E-1 | 7.26E-1 | 9.20E-1 | |
| SKAT-O | 7.32E-4 | 6.04E-1 | N/A | 8.07E-1 | 5.07E-1 | 8.34E-1 | |
| Number of rare variants | 5 | 8 | 11 | 8 | 11 | ||
a Meta-analysis of ARIC, WHI, BioVU, and HRS