Fig 2. Ptpn11^D61Y animals show reduced exploratory activity and mild impairment of memory specificity.

(A) Ptpn11^D61Y animals show a reduced run distance in the OFT. (B) The time spent in the center of field did not differ in the OFT. (C) Ptpn11^D61Y animals display normal levels of contextual fear memory. (D) In cued fear conditioning the differentiation of CS+ and CS- was reduced in the mutants compared to controls. (E, F) In the MWM, the escape latency during training (E) as well as the time spent in the target quadrant (T) in the first probe trial (F) are comparable between the genotypes indicating normal spatial memory in Ptpn11^D61Y (AR, adjacent right; O, opposite; AL adjacent left quadrant). (G) Ptpn11^D61Y animals swam shorter distances in the probe trial. Data are shown as mean ± SEM analyzed using unpaired t-test, one-way ANOVA or two-way repeated measures ANOVA (n = 10–12; *p<0.05).