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. 2017 Jan 23;38(4):551–560. doi: 10.1038/aps.2016.139

Figure 1.

Figure 1

Chromopeptide A is a novel class I HDAC inhibitor. (A) Chemical structures of chromopeptide A and FK228. (B) Selectivity profiling on HDAC enzymes of chromopeptide A and FK228. The indicated concentrations of chromopeptide A and FK228 were exposed to HDAC1-8 and the enzyme activity was determined by the protease-coupled assay. Bars represent the mean±SD. (C) Kinetic analysis of chromopeptide A and FK228 on HDAC1. Chromopeptide A and FK228 were exposed to different concentrations of Ac-peptide-AMC substrates with HDAC1. The alpha values and Ki values were determined in a mixed competitive inhibition fitted model. Bars represent the mean±SD.