Table 5. Stratification analysis of the association between lncRNA polymorphisms and hematologic toxicity.
| Gene | SNP | Subgroup | Additive |
Dominant |
Recessive |
|||
|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | |||
| ANRIL | rs1333049 | Male | 0.695 (0.466, 1.035) | 0.073 | 0.510 (0.285, 0.913) | 0.023* | 0.825 (0.422, 1.603) | 0.566 |
| HOTTIP | rs5883064 | Non-smoke | 1.973 (1.101, 3.533) | 0.022* | 1.857 (0.801, 4.306) | 0.149 | 3.807 (1.327, 10.920) | 0.013* |
| CCAT2 | rs6983267 | NSCLC | 0.614 (0.423, 0.891) | 0.010* | 0.522 (0.312, 0.875) | 0.014* | 0.542 (0.262, 1.122) | 0.099 |
| ANRIL | rs1333049 | More 57a | 0.601 (0.371, 0.975) | 0.039* | 0.734 (0.357, 1.509) | 0.401 | 0.299 (0.115, 0.775) | 0.013* |
| rs10120688 | Smoke | 1.497 (0.978, 2.291) | 0.063 | 1.858 (1.024, 3.371) | 0.041* | 1.394 (0.575, 3.382) | 0.462 | |
| H19 | rs2839698 | GP | 0.755 (0.455, 1.254) | 0.278 | 0.963 (0.516, 1.799) | 0.907 | 0.120 (0.015, 0.962) | 0.046* |
| HOTAIR | rs7958904 | SCC | 1.933 (1.038, 3.598) | 0.038* | 3.794 (1.679, 8.572) | 0.001* | 0.184 (0.019, 1.758) | 0.141 |
| GP | 1.529 (0.904, 2.586) | 0.113 | 2.354 (1.217, 4.553) | 0.011* | 0.337 (0.065, 1.736) | 0.193 | ||
| POLR2E | rs3787016 | Less 57b | 0.659 (0.414, 1.049) | 0.078 | 0.498 (0.251, 0.990) | 0.047* | 0.708 (0.319, 1.572) | 0.396 |
Abbreviations: SNP, single nucleotide polymorphism; OR, odd ratio; CI, confidence interval; NSCLC, non-small-cell lung cancer; SCC, squamous-cell carcinoma; GP, platinum+gemcitabine. More 57a, age more 57. Less 57b, age less 57.
*P<0.05.