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. 2017 Mar 6;38(4):581–590. doi: 10.1038/aps.2016.164

Table 5. Stratification analysis of the association between lncRNA polymorphisms and hematologic toxicity.

Gene SNP Subgroup Additive
Dominant
Recessive
      OR (95% CI) P OR (95% CI) P OR (95% CI) P
ANRIL rs1333049 Male 0.695 (0.466, 1.035) 0.073 0.510 (0.285, 0.913) 0.023* 0.825 (0.422, 1.603) 0.566
HOTTIP rs5883064 Non-smoke 1.973 (1.101, 3.533) 0.022* 1.857 (0.801, 4.306) 0.149 3.807 (1.327, 10.920) 0.013*
CCAT2 rs6983267 NSCLC 0.614 (0.423, 0.891) 0.010* 0.522 (0.312, 0.875) 0.014* 0.542 (0.262, 1.122) 0.099
ANRIL rs1333049 More 57a 0.601 (0.371, 0.975) 0.039* 0.734 (0.357, 1.509) 0.401 0.299 (0.115, 0.775) 0.013*
  rs10120688 Smoke 1.497 (0.978, 2.291) 0.063 1.858 (1.024, 3.371) 0.041* 1.394 (0.575, 3.382) 0.462
H19 rs2839698 GP 0.755 (0.455, 1.254) 0.278 0.963 (0.516, 1.799) 0.907 0.120 (0.015, 0.962) 0.046*
HOTAIR rs7958904 SCC 1.933 (1.038, 3.598) 0.038* 3.794 (1.679, 8.572) 0.001* 0.184 (0.019, 1.758) 0.141
    GP 1.529 (0.904, 2.586) 0.113 2.354 (1.217, 4.553) 0.011* 0.337 (0.065, 1.736) 0.193
POLR2E rs3787016 Less 57b 0.659 (0.414, 1.049) 0.078 0.498 (0.251, 0.990) 0.047* 0.708 (0.319, 1.572) 0.396

Abbreviations: SNP, single nucleotide polymorphism; OR, odd ratio; CI, confidence interval; NSCLC, non-small-cell lung cancer; SCC, squamous-cell carcinoma; GP, platinum+gemcitabine. More 57a, age more 57. Less 57b, age less 57.

*P<0.05.