Table 6. Association of gene-environment interaction and toxicities induced by platinum-based chemotherapy.

Type of toxicity	Model	Training Bal Acc	Testing Bal Acc	Sign test (P)	CV consistency
Overall toxicity	Regimen	0.5983	0.5897	0.0107*	10/10
	rs6983267 regimen	0.6252	0.5168	0.6230	5/10
	rs10120688 rs6983267 regimen	0.6777	0.5044	0.3770	5/10
Gastrointestinal toxicity	Age	0.5938	0.5431	0.1719	6/10
	rs2107425 age	0.6319	0.5420	0.0547	9/10
	rs2107425 rs6983267 regimen	0.6868	0.5104	0.1719	5/10
Hematological toxicity	Regimen	0.6165	0.6005	0.0547	10/10
	rs2839698 regimen	0.6469	0.5155	0.3770	4/10
	rs3787016 rs3807598 regimen	0.7098	0.5902	0.0107*	9/10

Abbreviations: Training Bal Acc, training balance accuracy; Testing Bal Acc, testing balance accuracy.

^*P<0.05.