Table 1. Cytotoxicity of BMA-155Cl in various human hepatic cell lines. Data are expressed as the mean±SD of three independent experiments.
| Cell lines | IC50 (μmol/L) |
|||
|---|---|---|---|---|
| 72 h | 48 h | 24 h | Dox (48 h) | |
| HepG-2 | 8.44±1.82 | 12.21±0.83 | 16.62±1.34 | 0.58±0.18 |
| SMMC-7721 | 8.93±1.25 | 12.58±1.84 | 20.62±1.89 | 0.6±0.076 |
| LX-2 | 13.66±1.15 | 20±3.38 | 29.23±1.44 | 0.91±0.22 |
| Plc-prf-5 | 16.35±3.39 | 28.57±4.5 | 32.55±1.0 | 0.59±0.079 |
| HL7702 | 36.17±3.16 | >40 | >40 | 1.12±0.2 |
The effects of BMA-155Cl on various human hepatocellular carcinoma cells (HepG-2, SMMC-7721, Plc-prf-5) and normal hepatic cells (LX-2, HL7702) were examined by MTT assay. The cells were treated with various concentrations of BMA-155Cl for 72, 48, and 24 h. The IC50 values of BMA-155Cl were then calculated.