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Nonspecific activation of p38 MAPK with anisomycin increases seizure frequency. A. Plot of seizure frequencies for individual animals under control and drug-treated conditions. Non-specific activation of p38 MAPK with ANI increased spontaneous convulsive seizure frequency in all four treated animals, in one case precipitating SE. B. Histograms of seizure duration are shown under control and ANI treatment.
