Table 1. Association of gene alterations with gene expression classifiers.

Marker	Classifier	GEP subgroup	Correlation	Adjusted P-value
CCND1a	UAMS	CD-1	0.38	<0.001
CCND1a	UAMS	CD-2	0.28	<0.001
CDKN2Cb	UAMS	PR	0.19	0.033
SF3B1c	UAMS	CD-2	0.23	0.029
WHSC1a	UAMS	MS	0.54	<0.001
WWOXa	UAMS	MF	0.60	<0.001
CDKN2Cb	GEP70	High risk	0.24	<0.001
RB1b,c	GEP70	High risk	0.22	0.0012
WHSC1	GEP70	High risk	0.25	<0.001
CCND1a	TC	t(11;14)	0.30	<0.001
CCND1a	TC	t(11;14)	0.43	<0.001
FGFR3	TC	t(4;14)	0.44	<0.001
IGHa	TC	t(14;20)	0.30	0.02
WHSC1	TC	t(4;14)	0.67	<0.001
WWOX	TC	t(14;16)	0.77	<0.001
TMB high	UAMS	MF	0.23	0.003
TMB intermediate	UAMS	PR	0.12	0.016

Abbreviations: MF, maf; PR, proliferation; TMB, tumor burden. Shown are associations with an adjusted P⩽0.05.

^aRearrangements.

^bLoss.

^cBase substitutions.