Table 2. Association of gene alterations with overall survival (Cox regression).

	Gene	HR	95% CI (lower)	95% CI (higher)	Adjusted P-value
Univariate	TP53a	2.48	1.77	3.49	<0.001
	CDKN2Cb	3.66	2.33	5.76	<0.001
	RB1a,b	4.07	2.63	6.29	<0.001
	WHSC1c	3.38	2.06	5.54	<0.001
	FAF1b	4.72	2.40	9.28	<0.001
	t(4;14)d	2.23	1.48	3.36	<0.001
Multivariate	TP53a	2.30	1.634	3.252	<0.001
	CDKN2Cb	1.30	2.317	5.799	<0.001
	RB1a,b	1.34	2.45	5.979	<0.001
	WHSC1c	1.13	1.874	5.091	<0.001

Abbbreviations: CI, confidence interval; GEP, gene expression profiling; HR, hazard ratio.

^aBase substitutions.

^bLoss.

^cRearrangements.

^dPredicted by GEP.