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. 2017 Feb 3;7(2):e522. doi: 10.1038/bcj.2017.2

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Copyright © 2017 The Author(s)

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Different bispecific antibody formats. Heavy chain sequences are depicted in dark blue, dark red and dark gray, whereas corresponding light chains are in similar but lighter colors. Linkers are shown by continuous lines and disulfide bonds, when shown, are illustrated in dotted lines. Antigen epitopes are shown by triangles and semicircles. scFv, single-chain Fv fragments; scBsTaFv, single-chain bispecific tandem fragment variable; BiTE, Bispecific T-cell Engager; bsscFv, bispecific single-chain Fv; BiKE, bispecific killer-cell engager; DART, Dual-Affinity Re-Targeting; TandAb, Tandem Diabodies; sctb, Single-chain Fv Triplebody; BIf, Bispecific scFv Immunofusion; DVD-Ig, Dual-Variable-Domain Immunoglobulin; VH, variable heavy chain; VL, variable light chain; CL, constant light chain; CH1-3, constant heavy chains 1 to 3.