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. 2017 Feb 3;7(2):e525. doi: 10.1038/bcj.2017.6

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Schematic presentation of major components in ECM derived from MKs and involved in PMF progression. The parentheses include reference numbers corresponding to the illustrated pathway. BM, bone marrow; bFGF, basic fibroblast growth factor; ECM, extracellular matrix; IL-1β, interleukin-1 beta; LOX, lysyl oxidase; MK, megakaryocyte; MMP, matrix metalloproteinase; MSC, mesenchymal stromal cell; PDGF-R, PDGF receptor; TGF-β, transforming factor beta; TIMP, tissue inhibitor of metalloproteinases; TSP-1, thrombospondin-1; PDGF, platelet derived growth factor; VEGF, vascular endothelial growth factor.