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. 2017 Feb 17;7(2):e527. doi: 10.1038/bcj.2017.8

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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PTC596 attenuates AML growth in vivo. (a) NSG mice were injected intravenously with MOLM-13 cells and were randomized into PTC596- and vehicle-treated groups. Leukemia burden expressed as percent human CD45⁺ cells is shown in peripheral blood (PB) on day 13 after treatment initiation. In one vehicle-treated mouse, PB was collected on day 11 as it became moribund (open circle). (b) Survival of MOLM-13 xenograft mice after treatment with PTC596 or vehicle control. Survival comparison was made with log-rank test.