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. 2017 Jan 5;8(1):e2533. doi: 10.1038/cddis.2016.439

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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A working model summarizing the role of Survivin in adipocyte homeostasis. During adipocyte differentiation, Survivin expression is gradually decreased and almost undetectable in mature adipocytes. Upon overnutrition condition, adipocytes are able to expression the Survivin gene via elevated insulin levels through the PI3K/mTOR pathway. Re-expressed Survivin inhibits isoproterenol-stimulated adipocyte lipolysis via decreased Adrb3 content, as well as increased Fsp27 expression. Survivin also attenuates TNFα-induced lipolysis and DNA damage-related stress responses. Taken together, the current findings suggest that Survivin may facilitate adipocyte maintenance in response to obesity-induced adipocyte stress