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Autophagolysosomes are swollen in AMD RPE. Swollen LAMP-1-positive organelles, commonly indicative of defective lysosomal function, are consistently observed in AMD RPE (white arrowheads, AMD 32 (a) and AMD 9 (c)), but not in healthy RPE (white arrows, Ctrl 10 (b) and Ctrl 6 (d)). Insets (1–8) are × 5 magnifications of indicated boxed regions, scale bar represents 20 μm
