Table 1. Genotyping and clinical information of AMD and control RPE.
| Donor Id# | Donor age (gender) | Clinical diagnosis | CFH (C: risk) | HTRA1 (A: risk) | LOC (T: risk) | Factor B (T: protective) | C2 (C: protective) | Smoking | Cause of death | Enucleation (h) |
|---|---|---|---|---|---|---|---|---|---|---|
| 006 | 72 (M) | CONTROL | CT | AG | GT | CC | GG | Quit in 1993 | Chronic obstructive pulmonary disease | 12 |
| 010 | 80 (M) | CONTROL | CC | AG | GT | CC | GG | Quit in 1984 | Acute myocardial infraction | 9.4 |
| 015 | 11 (M) | CONTROL | TT | AG | GT | CC | GG | No | Multiple trauma | 9.5 |
| 023 | 17 (M) | CONTROL | CT | GG | GG | CT | GG | N/D | Motor vehicle accident | 9 |
| 025 | 50 (M) | CONTROL | TT | GG | GG | CC | GG | No | Myocardial infraction | 17 |
| 009 | 68 (F) | AMD | TT | GG | GG | TT | GG | 2 ppd for 40 years | Stroke | 3 |
| 014 | 82 (M) | AMD | CT | AG | GT | CC | GG | 1 ppd for 40 years | Cardial related | 12 |
| 017 | 81 (M) | AMD | CC | AA | TT | CC | GG | N/D | Cardial arrest | 10.5 |
| 019 | 80 (F) | AMD | CT | GG | GG | CC | GG | No | GI bleed | 9 |
| 032 | 75 (F) | AMD | CT | AA | TT | CC | GG | No | Pancreatic cancer | 7 |
Abbreviations: F, female; M, male
The five clinically diagnosed AMD donors and five clinically normal donors (control) from which primary RPE cultures were established. The cause of death and time of enucleation are indicated. Genotyping data for known AMD-associated Single Nuclear Polymorphisms showing the haplotypes of each donor, carrying risk or protective alleles as marked in bold entries