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. 2017 Jan 19;8(1):e2559. doi: 10.1038/cddis.2016.455

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Tcf7l2 negatively regulates 3T3-L1 differentiation. (a-b) HFD feeding decreased Tcf7l2 and Tcf7l1 but not Tcf7 mRNA levels. (c) Illustration of the differentiation procedure with virus infection. (d) Detection of exogenous expression of TCF7L2 and TCF7L2DN in 3T3-L1 cells after virus infections for 48 h by western blotting with the HA-tag antibody. (e-f) Oil red O staining and semi-quantitative assessment of Oil red O content. (g) Triglyceride levels in differentiated 3T3-L1 cells with indicated virus infection. (h) Detection of genes that encode five adipogenic differentiation markers in differentiated 3T3-L1 cells infected with the correspondent adenovirus. N> or =3 for panels (a), (b) and (e–h). *P<0.05; **P<0.01; ***P<0.001. TCFDN, Ad-TCF7L2DN; miR-17, miR-17-5p