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. 2017 Jan 12;8(1):e2541. doi: 10.1038/cddis.2016.456

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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rtPA fails to reduce stroke-induced increases of IL-6 and CCL2 protein levels in the ischemic cortex of ColXV KO mice. IL-6 (a), CCL2 (b), TNF-α (c) and IFN-γ (d) protein levels at 3 days post injury in the contralateral (CL, black bars) and ipsilateral (IL, white bars) cortices of sham-operated and injured WT and ColXV KO mice thrombolysed or not with rtPA 20 min after TE stroke. Values plotted are mean±S.E.M. Kruskal–Wallis: P>0.05 for TNF-α and IFN-γ, P<0.0001 for IL-6 and CCL2. Mann–Whitney U-tests: *P<0.05, **P<0.01 compared to the contralateral hemisphere, ^#P<0.05 compared to the ipsilateral cortex of saline TE WT; N = 4-5 per group