Figure 6.
miR-224 mediates the in vivo tumorigenesis function of TAZ. (a and b) Nude mice were injected with 1 × 107 MG-63 stable cells. Tumors were dissected and photographed after 5 weeks. (c) Graph represents tumor volumes at the indicated days for the three groups: control, shTAZ and co-transfection of shTAZ and pre-miR-224; six mice in each group. Data are presented as mean±S.D. (n=6), *P<0.01. (d) Tumor weight averages of each mice group at the end of the experiment (day 35). Data are presented as mean±S.D. (n=6), *P<0.01. (e) Immunoblot analysis of TAZ in tumors from xenograft mice. (f) qRT-PCR analysis of miR-224 in tumors from xenograft mice