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. 2017 Jan 19;8(1):e2565. doi: 10.1038/cddis.2016.475

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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VPS15 expression in DD and GSDII muscle. (a) Immunoblot analyses of muscle biopsies for VPS15, VPS34, BECN1, GAA (in DD) and the loading control GAPDH in DD and in GSDII (b) patients. Ctrl, healthy control; ERT, biopsy after ERT; numbers, patient identifiers; I, first biopsy; II: second biopsy. (c) Densitometric analysis (percentage compared with control) of proteins normalized to GAPDH for DD and GSDII (d) patients. (e) Densitometric analysis (percentage compared with control) of GAA. The different GAA forms are specified: the inactive (110+95 kDa) and the active ones (76 and 70 kDa)