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. 2017 Jan 12;8(1):e2546. doi: 10.1038/cddis.2016.478

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The loss of CRB3 disrupts the formation of tight and adherens junctions. (a, b) A cell adhesion assay was performed to detect the adhesion of MCF10A cells. Scale bar, 50 μm **P<0.01. Data are mean±S.D. (c) The levels of the ZO-1, Claudin-1 and E-cadherin proteins were determined by immunoblotting. (d, e) The localization of ZO-1 and E-cadherin was examined in MCF10A cells grown in 2D culture. Scale bar, 25 μm. (f) The localization of E-cadherin in 3D cultures was detected using immunofluorescence staining. Scale bar, 25 μm