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. 2017 Jan 19;8(1):e2560. doi: 10.1038/cddis.2016.493

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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HBx/MDM2/CXCR4/OV6 expression predicts malignant clinicopathological features and a poor prognosis for patients with HBV-related HCC. (a) Representative IHC staining of MDM2, CXCR4 and OV6 in HBV-related HCC specimens are shown (scale bar=20 μm). Kaplan–Meier curves for overall survival (OS) and disease-free survival (DFS) were compared according to combinations of HBx and CXCR4 (b), MDM2 and CXCR4 (c), and CXCR4 and OV6 expression (d) to assess their prognostic significance in HCC patients (n=267)