Table 1. Clinicopathologic characteristics of HCC subtypes defined by OV6 and HBx expression.

	OV6/HBx expression
		Either high
HCC subtypes	Both high (n=72)	High HBx, low OV6 (n=63)	High OV6, low HBx (n=34)	Both low (n=98)	P-valuea
Sex
Male	63	54	28	91	0.307
Female	9	9	6	7
Age (year)b	51.6±1.2	49.6±1.3	48.6±1.9	50.4±1	0.487
HBeAg positive
Yes	25	10	4	20	0.021
No	47	53	30	78
AFP (ng/ml)
⩾ 400	54	34	20	59	0.066
< 400	18	29	14	39
Tumor size (cm)b	7.6±0.5	5.5±0.4	7.4±0.7	4.9±0.3	<0.001
Tumor number (count)b	1.3±0.1	1.2±0.1	1.4±0.1	1.1±0.03	0.004
Tumor differentiation grade
Well (I)	0	0	1	2	0.369
Intermediate (II–III)	72	63	33	96
Tumor satellites
Yes	49	45	28	69	0.493
No	23	18	6	29
Microvascular Invasion
Yes	51	45	23	44	<0.001
No	21	18	11	54
Recurrence
Yes	66	33	27	41	<0.001
No	6	30	7	57
Expired
Yes	67	24	24	16	<0.001
No	5	39	10	82
Risk-free survival time (mo)b	12.1±1.8	38.5±3.2	20.1±3.9	47.7±2.2	<0.001
Overall survival time (mo)b	20.3±2	48.8±2.7	29.1±4.2	59.4±1.3	<0.001

^aStatistical significance was caluculated by chi-square test or Fisher's exact test for categorical/binary measures and ANOVA for continuous measures.

^bData are presented as mean±S.D.