Table 4. Mutation age estimates of the c.802-510 8_810del17insGC indel mutation in the Chinese and Japanese populations.
| Method | rs7663027 | rs10013653 | rs7682918 | rs12507156 | rs397722245 | rs4862662 | rs13146272 | * | rs28698123 | rs7667777 | rs2276918 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| C>G | C>A | C>A | C>T | 605-40DELCT | G>T | C>A | C>T | C>G | A>G | ||
| Chinese | |||||||||||
| Risch et al15 | |||||||||||
| Single marker | 7044 | 2605 | 3306 | 4986 | 1510 | 1150 | 2278 | – | 2517 | 5208 | |
| Multiple marker haplotypea,b | 3400 | 4500 | |||||||||
| Goldstein et al17 | 8200 | 2245 | 2277 | 2250 | 1841 | 3985 | |||||
| Haplotype | 1900 | ||||||||||
| DMLE2: 2300 BC | 1040 (95% CI: 931–1237) | ||||||||||
| Japanesea | |||||||||||
| Risch et al | |||||||||||
| Single marker | – | – | – | – | – | – | – | – | 933 | 708 | |
| Multiple marker haplotypeb | 1100 | ||||||||||
| Goldstein et al | – | – | – | – | – | – | – | – | 933 | 300 | |
| DMLE2:2300 BC | 624 (95% CI: 538–738) | ||||||||||
*rs207482233 (c.802-8_10 DELINSGC).
a
Left haplotype uses CHM estimates of markers rs10013653-rs13146272 and markers 424862662-rs13146272 for multiple marker calculation.
b
Right haplotype uses CHM estimates of rs28698123-rs2276918 and rs7667777-rs2276918 for multiple marker calculation.