Table 2. Subcategories of variants based on scoring scheme.

Percentage (%)	Score	Subclass
≥90	43.2–48.0	VUS4	Probably pathogenic
80–89	38.4–43.1	VUS3	Likely pathogenic
70–79	33.6–38.3	VUS2	Unclear
60–69	28.8–33.5	VUS1	Unlikely pathogenic
<59	≤28.7	VUS0	Not pathogenic (neutral variant or weak modifier)

Abbreviation: VUS, variant of unknown significance.