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. 2017 Apr 2;23:1597–1606. doi: 10.12659/MSM.900218

Figure 2.

Figure 2

Overexpression of miR-181a inhibits autophagy. The mRNA and protein expressions of LC3II, LC3I, and Beclin 1 were detected after administration with MPP+ and/or transfection with miR-181a mimic or scramble. Non-treated cells were considered as a control group. (A, B) The mRNA and protein expressions of the LC3II/LC3I ratio were statistically decreased by MPP+ + miR-181a mimic. (C, D) The mRNA and protein expressions of Beclin 1 were significantly reduced by MPP+ + miR-181a mimic. ** P<0.01 compared to the control group; # P<0.05 compared to the MPP+ + miR-181a scramble group. MiR – microRNA; MPP+ – 1-methyl-4-phenylpyridinium ion; NS, no significance.