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. 2017 Apr 1;23:1583–1596. doi: 10.12659/MSM.904124

Figure 3.

Figure 3

Knockdown of ezrin changes the phenotype and significantly decreases the migratory and invasive potential of breast cancer cells. (A) The phenotype of MDA-MB-231 cells after ezrin knockdown changed from spindle to oval. Magnification ×100. (B) The shape of SUM1315 after ezrin knockdown had no visible change. Magnification ×100. (C, D) MDA-MB-231 and SUM1315 cells transfected with shRNA against ezrin were subsequently subjected to Transwell migration assay and Matrigel invasion assay. Representative photographs (upper panel) and quantification (lower panel) are shown. Columns: average of 3 independent experiments, * p<0.05, ** p<0.01. Magnification ×100.