Supplementary Table 1.
Identification of up- and down-regulated proteins in MDA-MB-231br cells compared to MDA-MB-231 cells.
| No. | Accession No | AC | Theor. mol | Measured | Sequence | Peptides a | Fold chang | Student T |
|---|---|---|---|---|---|---|---|---|
| 1 | gi|7706425 | LSM8 | 10.4/4.34 | 11.5/4.11 | 0.82 | 4 | 0 | 6.9501 |
| 2 | gi|38511503 | LOC400581 | 13.2/7.88 | 14.4/7.73 | 0.57 | 11 | 0 | 3.32884 |
| 3 | gi|5453740 | MRCL3 | 19.8/4.67 | 21.0/4.46 | 0.63 | 12 | 0 | 22.6371 |
| 4 | gi|11957604 | GLO1 | 21.0/5.12 | 23.1/5.38 | 0.29 | 19 | 0.1458951 | 5.8117 |
| 5 | gi|11958606 | PRDX6 | 22.8/5.98 | 20.6/5.65 | 0.56 | 14 | 0.3751647 | 3.13876 |
| 6 | gi|4504517 | HSPB1 | 22.8/5.98 | 21.5/6.26 | 0.49 | 11 | 1.7085594 | 6.85507 |
| 7 | gi|4506195 | PSMB2 | 23.0/6.51 | 17.7/5.28 | 0.37 | 11 | 0.5424243 | 3.47661 |
| 8 | gi|11962339 | RANBP1 | 23.5/5.19 | 26.9/4.31 | 0.42 | 16 | 0.5717237 | 5.58285 |
| 9 | gi|31645 | GAPDH | 31.7/7.15 | 35.9/4.79 | 0.57 | 27 | 2.3023371 | 3.26693 |
| 10 | gi|914957 | GRB2 | 25.3/5.89 | 28.4/5.48 | 0.51 | 13 | ND | 5.22913 |
| 11 | gi|20149675 | TUBB | 26.8/5.15 | 31.2/4.82 | 0.46 | 12 | 3.1617546 | 9.1124 |
| 12 | gi|16357477 | CDC34 | 26.9/4.41 | 28.0/4.2 | 0.32 | 9 | 0.3679367 | 3.0581 |
| 13 | gi|44979607 | IMPDH2 | 27.3/5.84 | 29.4/6.1 | 0.6 | 9 | 0.4022986 | 5.13788 |
| 14 | gi|48145973 | NDUFV2 | 27.7/8.22 | 26.3/8.67 | 0.33 | 8 | 0.3474179 | 2.92579 |
| 15 | gi|19298714 | PGLS | 27.8/5.7 | 25.6/5.37 | 0.37 | 9 | 0.4460076 | 3.16474 |
| 16 | gi|4758484 | GSTO1 | 27.8/6.23 | 26.5/6.51 | 0.48 | 15 | 0.2449022 | 4.34464 |
| 17 | gi|19378506 | PSPHL;ACTG1 | 28.5/5.2 | 23.2/3.97 | 0.45 | 12 | 0.4615403 | 3.08667 |
| 18 | gi|17402904 | EXOSC6 | 28.5/6.06 | 31.9/5.18 | 0.3 | 12 | 0.2836561 | 4.7922 |
| 19 | gi|62897753 | hCG_2015269 | 29.0/6.67 | 26.8/6.34 | 0.79 | 19 | 0.3179457 | 3.64943 |
| 20 | gi|19298714 | ERP29 | 29.0/6.77 | 27.7/7.05 | 0.39 | 10 | 0.4765053 | 3.36723 |
| 21 | gi|4826659 | CAPZB | 29.6/6.45 | 24.3/5.22 | 0.64 | 26 | 0.4184514 | 2.90687 |
| 22 | gi|19438056 | LASP1 | 30.1/6.61 | 33.5/5.73 | 0.58 | 8 | 0.2488259 | 5.5738 |
| 23 | gi|22652991 | TPI1 | 31.1/5.65 | 35.3/3.29 | 0.56 | 14 | 0.4883441 | 7.47102 |
| 24 | gi|21361454 | PYCR2 | 34.4/8.48 | 37.5/8.07 | 0.54 | 24 | 0.3732397 | 5.90677 |
| 25 | gi|18906542 | HNRPC | 32.4/4.94 | 36.8/4.61 | 0.53 | 20 | 0.5408701 | 6.3532 |
| 26 | gi|12803709 | CK14 | 32.4/4.97 | 33.5/4.76 | 0.33 | 17 | 0.4598442 | 3.63144 |
| 27 | gi|11056044 | PPA1 | 33.1/5.54 | 35.3/5.8 | 0.5 | 17 | 0.4610924 | 2.78434 |
| 28 | gi|5174447 | TST | 33.6/6.77 | 32.3/7.22 | 0.37 | 14 | 0.4618559 | 2.78215 |
| 29 | gi|10437514 | SUHW4 | 35.1/8.68 | 32.9/8.35 | 0.42 | 14 | ND | 11.2023 |
| 30 | gi|11962858 | DNAH3 | 473.8/6.04 | 472.5/6. | 0.27 | 14 | 0.3843506 | 2.9416 |
| 31 | gi|4826643 | ANXA3 | 36.5/5.63 | 31.2/4.4 | 0.56 | 23 | 0.5335611 | 5.71278 |
| 32 | gi|19438981 | CNN3 | 36.6/5.69 | 35.2/6.14 | 0.49 | 17 | 3.3243097 | 7.20813 |
| 33 | gi|2119276 | TUBB | 48.1/4.7 | 45.9/4.37 | 0.25 | 14 | 1.8615634 | 3.20717 |
| 34 | gi|73976124 | HNRPA2B1 | 37.5/8.97 | 36.1/9.25 | 0.46 | 12 | 2.5249017 | 6.79964 |
| 35 | gi|17402893 | PSAT1 | 40.8/7.56 | 35.5/6.33 | 0.55 | 26 | 1.6654277 | 3.88025 |
| 36 | gi|19437787 | ARFIP2 | 37.9/5.72 | 41.4/4.84 | 0.38 | 12 | 1.7420536 | 2.80585 |
| 37 | gi|22104024 | PPP1CB | 38.0/5.84 | 42.2/3.48 | 0.22 | 8 | 0.3430111 | 4.85873 |
| 38 | gi|11960877 | PPP1CB | 38.0/5.84 | 41.1/5.43 | 0.4 | 23 | 0.4678427 | 3.05192 |
| 39 | gi|6912280 | AHSA1 | 38.4/5.41 | 33.1/4.18 | 0.19 | 8 | 4.3644831 | 5.00035 |
| 40 | gi|7305503 | STOML2 | 38.6/6.88 | 42.1/6 | 0.52 | 18 | 0.2565899 | 4.2268 |
| 41 | gi|11959799 | ANXA2 | 38.8/7.57 | 36.6/7.24 | 0.6 | 20 | 2.2824303 | 4.00567 |
| 42 | gi|4506127 | PRPS1 | 35.3/6.51 | 34.0/6.79 | 0.47 | 21 | 1.9003629 | 5.43115 |
| 43 | gi|93277122 | BUB3 | 32.1/8.4 | 26.8/7.17 | 0.43 | 15 | 3.4236124 | 10.8789 |
| 44 | gi|4503895 | GALK1 | 42.7/6.04 | 46.9/3.68 | 0.35 | 17 | 6.5938433 | 3.2962 |
| 45 | gi|11960222 | CKB | 42.9/5.34 | 46.0/4.93 | 0.45 | 15 | 2.6276618 | 3.86433 |
| 46 | gi|15825518 | SERPINB7 | 43.2/6.34 | 47.6/6.01 | 0.34 | 12 | 0.2890603 | 11.6406 |
| 47 | gi|19438418 | HSPA8 | 71.1/5.37 | 72.2/5.16 | 0.24 | 14 | 1.8781699 | 3.44432 |
| 48 | gi|5174529 | MAT2A | 44.0/6.02 | 46.1/6.28 | 0.32 | 14 | 0.3873342 | 3.38533 |
| 49 | gi|19378506 | ACTB | 45.5/5.82 | 44.1/6.27 | 0.27 | 7 | 2.5188648 | 4.86371 |
| 50 | gi|5729991 | PSMC4 | 47.5/5.09 | 45.2/4.76 | 0.45 | 19 | 2.9751505 | 7.05399 |
| 51 | gi|20328236 | ENO1 | 47.5/7.01 | 50.9/6.13 | 0.33 | 14 | 0.4514455 | 5.84011 |
| 52 | gi|20328236 | ENO1 | 47.5/7.01 | 51.7/4.65 | 0.38 | 14 | 2.1757631 | 2.78494 |
| 53 | gi|28872725 | PSMD11 | 47.8/6.08 | 50.9/5.67 | 0.25 | 12 | 2.2969517 | 4.67432 |
| 54 | gi|35071 | MTHFD2 | 38.0/8.86 | 42.4/8.53 | 0.02 | 11 | 3.0997653 | 3.33509 |
| 55 | gi|21623852 | PSMC3 | 49.5/5.13 | 48.1/5.58 | 0.22 | 19 | 3.0467243 | 3.32863 |
| 56 | gi|21623852 | PSMC3 | 49.5/5.13 | 47.3/4.8 | 0.47 | 24 | 1.9425454 | 4.2506 |
| 57 | gi|20328236 | ENO1 | 47.5/7.01 | 46.2/7.29 | 0.63 | 29 | 1.5667183 | 4.24397 |
| 58 | gi|16507237 | VIM | 49.7/5.19 | 44.4/3.96 | 0.4 | 20 | 2.3352391 | 3.4501 |
| 59 | gi|14043072 | HNRPA2B1 | 37.5/8.97 | 40.9/8.09 | 0.5 | 25 | 2.118541 | 2.97696 |
| 60 | gi|11960877 | TUBB2A | 50.3/4.78 | 54.5/2.42 | 0.42 | 16 | 2.5802857 | 3.58321 |
| 61 | gi|28948869 | VIL2 | 69.5/5.94 | 72.6/5.53 | 0.39 | 18 | 2.6162373 | 3.95062 |
| 62 | gi|11960683 | GDI2 | 51.1/6.11 | 55.5/5.78 | 0.38 | 16 | 4.2414899 | 8.61448 |
| 63 | gi|38569475 | MTX1 | 51.7/9.8 | 46.4/8.57 | 0.36 | 14 | ND | 10.9218 |
| 64 | gi|449441 | UGP2 | 55.8/7.69 | 59.2/6.81 | 0.39 | 24 | 3.9755451 | 4.09809 |
| 65 | gi|48255968 | UGP2 | 55.8/7.69 | 60.0/5.33 | 0.52 | 27 | 2.5612084 | 6.32672 |
| 66 | gi|66933016 | IMPDH2 | 56.2/6.44 | 59.4/6.03 | 0.42 | 20 | 0.4828852 | 10.5545 |
| 67 | gi|11961763 | CCT2 | 57.8/6.01 | 62.2/5.68 | 0.39 | 15 | 4.6695429 | 4.39079 |
| 68 | gi|4557976 | ALDOA | 39.9/8.3 | 41.0/8.09 | 0.47 | 20 | 2.0385729 | 3.2317 |
| 69 | gi|22104614 | CCT5 | 60.1/5.45 | 62.2/5.71 | 0.53 | 26 | 2.3538723 | 4.52031 |
| 70 | gi|20151189 | GLUD1 | 61.7/7.66 | 60.3/8.11 | 0.33 | 13 | 0.3442582 | 9.36776 |
| 71 | gi|19437434 | HSPA5 | 72.5/5.07 | 70.3/4.74 | 0.71 | 24 | 5.0750799 | 3.96361 |
| 72 | gi|11463825 | STIP1 | 63.2/6.4 | 66.7/5.52 | 0.51 | 37 | 3.6341375 | 2.79519 |
| 73 | gi|16915936 | MGAT4B | 65.1/8.38 | 69.3/6.02 | 0.29 | 10 | 2.8100682 | 3.95651 |
| 74 | gi|9910460 | ZNF714 | 69.3/9.16 | 72.4/8.75 | 0.3 | 9 | 2.8886894 | 3.2727 |
| 75 | gi|182087 | CTTN | 61.9/5.28 | 66.3/4.95 | 0.32 | 21 | 7.0312418 | 6.24639 |
| 76 | gi|13676857 | HSPA2 | 70.3/5.56 | 68.9/6.01 | 0.27 | 15 | 2.6325321 | 3.0962 |
| 77 | gi|13676857 | HSPA2 | 70.3/5.56 | 68.1/5.23 | 0.44 | 29 | ND | 37.1179 |
| 78 | gi|1017722 | ZNF85 | 70.9/9.48 | 69.6/9.76 | 0.26 | 14 | 3.6214245 | 3.22252 |
| 79 | gi|57014047 | LMNA | 70.9/8.55 | 65.6/7.32 | 0.5 | 31 | 5.398146 | 3.33403 |
| 80 | gi|29645294 | SNIP | 112.7/9.32 | 116.1/8. | 0.24 | 16 | 2.8558356 | 3.07003 |
| 81 | gi|542991 | ROR2 | 80.8/7.3 | 85.1/4.94 | 0.51 | 12 | ND | 11.6562 |
VIL2 – Chain A, structure of the active ferm domain of ezrin; CTTN – cortactin.